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Comparisons

Mounjaro vs Wegovy

Mounjaro contains tirzepatide and acts on two hormone systems (both GLP-1 and GIP); Wegovy contains semaglutide and acts only on GLP-1. Both are weekly injections and available by prescription only, through a doctor and pharmacy. Studies indicate a greater average weight loss with tirzepatide.

Difference in mechanism of action

Semaglutide (Wegovy) is a GLP-1 receptor agonist. Tirzepatide (Mounjaro) is a dual agonist that acts on both the GLP-1 and the GIP receptor. Both influence appetite and satiety, among other things, via receptors in the brain and the gastrointestinal tract. The added GIP effect of tirzepatide is the most important mechanistic difference.

Average weight loss

In a head-to-head study (SURMOUNT-5), the average weight loss was indicatively greater with tirzepatide (around 20%) than with semaglutide (around 14%). Results vary widely from person to person and depend on dosage, diet, physical activity and individual factors.

The percentages mentioned are indicative averages from research and say nothing about an individual result. A doctor assesses suitability.

Use and dosing

FeatureMounjaroWegovy
Active substanceTirzepatideSemaglutide
Acts onGLP-1 + GIPGLP-1
AdministrationWeekly injectionWeekly injection
Registered forType 2 diabetes and weight managementWeight management

Both involve a gradual dose titration that the doctor determines. Consult the package leaflet and the Dutch Farmacotherapeutisch Kompas for details.

Costs and reimbursement

Costs vary per medicine and dosage, and reimbursement depends on the indication and your insurance policy. See our neutral overviews on costs and reimbursement.

Frequently asked questions

Does Mounjaro work better than Wegovy?
In a head-to-head study, the average weight loss was greater with tirzepatide, but results vary from person to person. A doctor assesses what is appropriate.
What is the most important difference between the two?
Mounjaro (tirzepatide) acts on both GLP-1 and GIP, whereas Wegovy (semaglutide) acts only on GLP-1.
Are both medicines prescription-only?
Yes. Both are available by prescription only, through a doctor and pharmacy.

Official sources on this topic

Independent, authoritative information from official bodies:

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Wegovy vs Ozempic→Ozempic or Mounjaro→Medicine: Mounjaro→Medicine: Wegovy→