Saxenda vs Wegovy

The key difference: daily vs weekly

Saxenda contains liraglutide and is injected once a day. Wegovy contains semaglutide and is injected once a week. For those who would rather inject as little as possible, the weekly frequency of Wegovy may be more convenient. Both are GLP-1 receptor agonists; read how that works at how GLP-1 works. How to inject safely is explained at injecting.

Saxenda and Wegovy side by side

Action and ease of use

Both medicines slow gastric emptying and give a feeling of fullness, which reduces appetite. The difference in duration of action explains the frequency: liraglutide acts for a shorter time (daily), semaglutide for longer (weekly). With both, the dose is built up step by step to limit side effects; see dose titration. A doctor assesses the effect after a few weeks and discusses continuation. Not sure whether you are suitable? See who it is suitable for.

Cost and reimbursement

Costs vary by medicine and pharmacy; a current overview is available at cost. Reimbursement depends on your indication and health insurance policy and is subject to strict conditions — read more about this at reimbursement. The daily Saxenda pen and the weekly Wegovy pen can work out differently in total monthly cost; discuss this with your doctor and pharmacy during the intake.

Which medicine when?

The choice depends on your situation, preferences and how your body responds. Those who are reluctant to inject daily may find the weekly Wegovy more convenient. On the other hand, daily dosing can offer advantages when adjusting the dose. This is a decision you make together with the doctor. A broader comparison with other medicines can be found at Saxenda vs Mounjaro and Saxenda vs Ozempic.

Frequently asked questions