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Mysimba or GLP-1?

Mysimba is a tablet containing bupropion and naltrexone and is not a GLP-1 medicine; it works through a different mechanism than GLP-1 injections. It may be considered for people who would rather not use an injection. Both options are prescription-only and available exclusively through a doctor and pharmacy; a doctor assesses suitability.

Difference in how they work

Mysimba combines bupropion (which influences the reuptake of dopamine and noradrenaline) and naltrexone (an opioid antagonist). Together they can influence appetite and feelings of hunger. GLP-1 medicines work via the GLP-1 receptor and influence satiety and appetite, among other things. So they have different mechanisms of action.

Use and dosage form

FeatureMysimbaGLP-1 injections
TypeTabletInjection (subcutaneous)
Active substanceBupropion + naltrexoneE.g. semaglutide or liraglutide
AdministrationDaily, oral (titration schedule)Weekly or daily
No injection neededYesNo

Mysimba involves a titration schedule in which the number of tablets is built up over several weeks. The doctor determines the dosage.

For whom is Mysimba considered?

Mysimba is registered for weight management in adults with obesity (BMI ≥ 30) or overweight (BMI ≥ 27) with weight-related conditions, alongside diet and increased physical activity. For people who do not want an injection, a tablet may be a consideration. Whether it is suitable and safe depends on medical factors and any other medication use.

Mysimba cannot be used together with certain medicines (such as opioids). A doctor assesses suitability; consult the package leaflet and the Dutch Farmacotherapeutisch Kompas.

Difference in effect

The average weight loss differs per medicine and per person. With Mysimba, it is generally advised to reconsider the treatment if there is insufficient effect after several months. Figures on average weight loss are indicative and say nothing about an individual result.

Frequently asked questions

Is Mysimba a GLP-1 medicine?
No. Mysimba contains bupropion and naltrexone and works through a different mechanism than GLP-1 medicines.
Is Mysimba an injection?
No, Mysimba is a tablet taken daily according to a titration schedule.
Can I get Mysimba without a prescription?
No. Mysimba is prescription-only and available only through a doctor and pharmacy.

Official sources on this topic

Independent, authoritative information from official bodies:

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