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Side effects & safety

Limiting nausea

Nausea and stomach complaints are the most common side effects of GLP-1 medication and can often be limited with simple lifestyle adjustments, such as eating smaller portions and avoiding fatty, heavy food. The complaints are usually strongest in the first weeks and after a dose increase. Important: never adjust your dosage yourself and always consult your doctor if complaints persist. This is general information and not medical advice.

Tips around eating and drinking

Many people find that these general adjustments help:

  • Eat smaller portions and spread them throughout the day.
  • Eat slowly and stop in time; the medication makes you feel full sooner.
  • Avoid fatty, fried and heavy food; this can worsen nausea.
  • Choose easily digestible meals and drink enough water, spread throughout the day.
  • Don't lie down flat immediately after eating.

Gradual titration under supervision

Most gastrointestinal complaints arise during the titration phase. A doctor therefore increases the dose step by step, so the body can get used to it.

Never increase or decrease your dosage on your own initiative. If you feel the titration pace is too fast, discuss this with your doctor; sometimes the schedule can be adjusted.

When should you consult your doctor?

Lifestyle tips can relieve mild complaints, but are no substitute for medical assessment. Contact your doctor or pharmacist in case of:

  • Nausea or vomiting that persists or is severe
  • Signs of dehydration (passing little urine, dizziness, dry mouth)
  • Persistent or severe abdominal pain
  • Complaints that prevent you from eating or drinking enough
Persistent severe abdominal pain may indicate a serious side effect. In that case, contact your doctor or the out-of-hours GP service immediately.

Reporting side effects

Are you experiencing side effects? Report them to the Netherlands Pharmacovigilance Centre Lareb via www.lareb.nl and consult the package leaflet of your product for a complete overview.

Frequently asked questions

How long does the nausea last?
For many people, nausea is strongest in the first weeks and shortly after a dose increase, and decreases afterwards. If it persists, consult your doctor.
Does eating less help against nausea?
Smaller portions, eating slowly and avoiding fatty/heavy food can relieve complaints. Do still eat and drink enough; if your intake is insufficient or you become dehydrated, contact your doctor.
Can I lower my dose if I feel nauseous?
Never adjust the dosage yourself. Discuss persistent complaints with your doctor, who can adjust the titration schedule if necessary.

Official sources on this topic

Independent, authoritative information from official bodies:

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